George Clooney, Ashlee Simpson S51E51 - George Clooney, Ashlee Simpson 2005
Dave shocks the audience with the news that Oprah Winfrey will be a guest on the show a week from Thursday; Biff undergoes Lasek eye surgery; George Clooney promotes "Syriana."
- Released: 2005-11-21
- Runtime: 50 minutes
- Genre:
- Stars: David Letterman, Paul Shaffer, Alan Kalter
- Director: